UNC 0224

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UNC 0224

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1197196-48-7

包装与价格：

包装	价格(元)
10mg	电议
50mg	电议

产品介绍

UNC 0224 是一种有效的选择性组蛋白甲基转移酶 G9a 抑制剂，Ki 为 2.6 nM，IC50 为 15 nM，Kd 为 23 nM。 UNC 0224 还有效抑制 b\u003eGLP，检测依赖的 IC50 值为 20-58 nM。 UNC 0224 对 SET7/9、SET8/PreSET7、PRMT3 和 JMJD2E 无效。

Cas No.	1197196-48-7
化学名	7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
Canonical SMILES	CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)C)OC)OCCCN(C)C
分子式	C₂₆H₄₃N₇O₂
分子量	485.67
溶解度	≥ 48.6mg/mL in DMSO, ≥ 44 mg/mL in EtOH
储存条件	Store at 4℃
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	UNC0224 is a potent and selective G9a inhibitor with IC50 of 15 nM in the G9a Thioglo assay.IC50 value: 15 nM [1]Target: G9aUNC0224 (Compound 8) also potently inhibited GLP with an IC50 of 20 nM and 58 nM in the Thioglo assay and and AlphaScreen, respectively. 8 was more than 1000-fold selective for G9a over SET7/9 (a H3K4 HMT) and SET8/PreSET7 (a H4K20 HMT) in Thioglo-based biochemical assays [1] [2]. References: [1]. Liu F, et al. Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. J Med Chem. 2009 Dec 24;52(24):7950-3. [2]. Liu F, et al. Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. J Med Chem. 2010 Aug 12;53(15):5844-57.