| Cas No. | 1011301-27-1 |
| 别名 | Tenovin 3;Tenovin3 |
| 化学名 | N-[(4-aminophenyl)carbamothioyl]-4-tert-butylbenzamide |
| Canonical SMILES | CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)N |
| 分子式 | C18H21N3OS |
| 分子量 | 327.44 |
| 溶解度 | ≥ 14.45mg/mL in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Tenovin SAR Studies Aimed at Increasing Water Solubility | ID | | p53 Increasea | K40Ac Tubulin Increaseb | SirT2 Inhibitionc |
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| R1 | R2 | | | | | Tenovin-1 | tBu | NHCOCH3 | + | + | + | | Tenovin-2 | tBu | NHCOCH(CH3)2 | + | + | + | | Tenovin-3 | tBu | NH2 | + | + | + | | Tenovin-4 | N3 | NHCOCH3 | − | − | − | | Tenovin-5 | tBu | NHCOPh | + | + | + | | Tenovin-6 | tBu | NHCO(CH2)4NMe2.HCl | + | + | + |
- a Ability to increase p53 levels was determined in MCF-7 cells treated for 6 hr at 10 μM.
- b Ability to increase K40 Ac-tubulin levels was determined in H1299 cells treated
- c SirT2 inhibition assessed using a compound concentration of 10 or 30 μM depending on the compound's solubility in the assay buffer.
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