| CAS NO: | 176957-55-4 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 176957-55-4 |
| 别名 | (2E,5E)-2,5-二(2-噻吩基亚甲基)环戊酮 |
| 化学名 | (2Z,5E)-2,5-bis(thiophen-2-ylmethylidene)cyclopentan-1-one |
| Canonical SMILES | C1CC(=CC2=CC=CS2)C(=O)C1=CC3=CC=CS3 |
| 分子式 | C15H12OS2 |
| 分子量 | 272.39 |
| 溶解度 | ≥ 3.4mg/mL in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | CCT007093 is a small-molecule chemical inhibitor of PPM1D with IC50 value of 8.4μM [1]. CCT007093 is a thienylidene cyclopentanone and shows a potent inhibition of PPM1D in the in vitro assay when using the recombinant phospho-P38 as a substrate. In cellular assay, CCT007093 shows specificity for MCF-7 cells over HeLa cells. It reduces 40% viability of the cells after 2 days. It is found that the cell death induced by CCT007093 is dependent on P38 kinase activity. CCT007093 mimics the effect of PPM1D RNAi in activating P38 kinase. It induces P38 phosphorylation at 4 h post-exposure in MCF-7 cells and the loss of viability can be rescued by SB203580, the specific P38 inhibitor [1]. References: |
m.cnreagent.com