SP-23 (SP23) is a novel, first-in-class and potent STING-targeting PROTAC degrader based on C-170 (STING inhibitor) with anti-inflammatory effects. In degrades STING with a DC50 of 3.2 μM. SP23 exerted high anti-inflammatory efficacy in a cisplatin-induced acute kidney injury mouse model by modulating the STING signaling pathway. Taken together, SP23 represents the first PROTAC degrader of STING deserving further investigation as a new anti-inflammatory agent.

纯度：≥98%

CAS：2762552-74-7