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Heptelidic Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Heptelidic Acid图片
CAS NO:57710-57-3
包装与价格:
包装价格(元)
250μg电议
1mg电议

产品介绍
庚酸(Koningic acid)是一种倍半萜类抗生素。
Cas No.57710-57-3
别名萜烯七脂酸; Koningic acid
Canonical SMILESCC(C)[C@H]1CC[C@@]2(CO2)[C@]3([H])[C@]1([H])C=C(C(O)=O)COC3=O
分子式C15H20O5
分子量280.3
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Glyceraldehyde 3-phosphate dehydrogenase (GAPDH), a key enzyme in carbohydrate metabolism, reversibly catalyzes the conversion of GAP to 1,3-bisphosphoglycerate and NAD+. Heptelidic acid is a sesquiterpene lactone produced by the fungus T. koningii that was shown to have antibiotic activity against anaerobic bacteria such as Bacteroides. It acts as an irreversible inhibitor of GAPDH that binds to the cysteine-149 residue at the active site of the enzyme (Ki = 1.6 µM). It can selectively induce apoptosis in high-glycolytic cancer cells by inhibiting the generation of ATP in the glycolytic pathway. Heptelidic acid is also a selective and competitive inhibitor of mammalian DNA polymerases β and λ as well as terminal deoxynucleotidyl transferase in family X of DNA polymerases (Kis range from 5.2-9.5 µM).