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T 26c disodium salt
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
T 26c disodium salt图片
CAS NO:869298-22-6
包装与价格:
包装价格(元)
5mg电议
25mg电议

产品介绍
Cas No.869298-22-6
Canonical SMILESCOC1=CC=CC(CNC(C2=NC(C3=C(SC=C3COCC4=CC=C(C(O[Na])=O)C=C4)N2[Na])=O)=O)=C1
分子式C24H19N3Na2O6S
分子量523.47
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Highly potent and selective MMP13 inhibitor (IC50 = 6.9 pM). Exhibits >2600-fold selectivity for MMP13 over related MMPs. Inhibits degradation of bovine nasal septum cartilage explants in vitro . Orally bioavailable.

Nara et al (2014) Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1" binding site. Bioorg.Med.Chem. 22 5487 PMID:25192810