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Pep 2-8
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1541011-97-5
包装:1mg
市场价:2043元

产品介绍
Pep 2-8 是一种 PCSK9 抑制剂,结合 KD 为 0.7 μM,IC50 为 1.4 μM。
Cas No.1541011-97-5
分子式C83H110N16O24
分子量1715.88
溶解度Soluble 2mg/mL in PBS (pH 7.4)
储存条件store at -20°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.

Zhang et al (2014) Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor. J.Biol.Chem. 289 942 PMID:24225950