| 包装: | 1mg |
| 市场价: | 450元 |
7-Ketolithocholic acid (3α-hydroxy-7-oxygen-5β-cholic acid) is a kind of bile acid, 7-Ketolithocholic acid can be absorbed, 7-ketolithocholic acid inhibits the production of endogenous bile acid, and can affect the secretion of biliary cholestero.
Animal models | 5 male subjects with gallstones (mean age, 55 yr) |
Preparation Method | 400 mg/day of uniformly labeled 7-ketolithocholic acid (sp act, 1000 * 100 dpm/mg) was fed to each patient daily for 2 wk and the specific activities of chenodeoxycholic acid and ursodeoxycholic acid in bile were measured every other day. |
Dosage form | 400 mg/day for 2 wkGBP¨ Intravenous injectionGBP(C) |
Applications | 7-ketolithocholic acid is absorbed, and suppresses endogenous bile acid production and biliary cholesterol secretion. |
| 产品描述 | 7-Ketolithocholic acid (3α-hydroxy-7-oxygen-5β-cholic acid) is a kind of bile acid, 7-Ketolithocholic acid can be absorbed, 7-ketolithocholic acid inhibits the production of endogenous bile acid, and can affect the secretion of biliary cholesterol[1，2]. After 7-ketolithocholic acid (400 mg/day) was administered orally for 14 days, biliary bile acid composition changed: The proportion of cholic acid decreased (from 45% to 19%), deoxycholic acid decreased (from 15% to 10%), chenodeoxycholic acid increased markedly (from 36% to 59%), ursodeoxycholic acid increased (from 36% to 59%), ursodeoxycholic acid increased (from 2% to 7%), and lithocholic acid increased (from 2% to 5%), while only trace amounts of 7-ketolithocholic acid were detected. During this treatment, the biliary lithogenic index fell from 2.6 to 0.9 and was accompanied by a pronounced drop in biliary cholesterol concentration[2]. References: |
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