| CAS NO: | 152-11-4 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| 25g | 电议 |
| 50g | 电议 |
| Molecular Weight (MW) | 491.06 |
|---|---|
| Formula | C27H38N2O4.HCl |
| CAS No. | 152-11-4 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 98 mg/mL (199.6 mM) |
| Water: 50 mg/mL (101.8 mM) | |
| Ethanol: 12 mg/mL (24.4 mM) | |
| Other info | Chemical Name: 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile hydrochloride InChi Key: DOQPXTMNIUCOSY-UHFFFAOYSA-N InChi Code: InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H SMILES Code: N#CC(C(C)C)(C1=CC=C(OC)C(OC)=C1)CCCN(CCC2=CC=C(OC)C(OC)=C2)C.[H]Cl |
| Synonyms | CP-16533-1; Lekoptin; Izoptin; CP16533-1; CP 16533-1; (±)-Verapamil hydrochloride; Isoptine, Isoptin, Verapamil HCl, Verapamil, Calan, Cordilox, Dexverapamil, Falicard, Finoptin, Hydrochloride, Iproveratril, |
| In Vitro | In vitro activity: The enzyme hydrolase activity of recombinant CES2 is substantially inhibited by diltiazem and verapamil (Ki = 0.25 ± 0.02 and 3.84 ± 0.99μM, respectively). Cell Assay: Cells (1×105) are treated with 10 nM Bortezomib and/or 70 μM Verapamil for 16 hours and incubated for another 4 hours with Alamar-Blue. Activity of the mitochondrial dehydrogenase results in conversion of the coloring, which is followed by measurement of the absorption using a spectrophotometer. |
|---|---|
| In Vivo | Verapamil confers an anti-arrhythmic effect via calcium influx inhibition, inhibition of oxygen consumption and accompanied by preservation of Cx43 protein in rat heart. |
| Animal model | Rats |
| Formulation & Dosage | Adult male Sprague-Dawley (SD) rats (250–350 g) are used. Verapamil (1 mg/kg) is injected i.v. into a femoral vein 10 min prior to ischemia. A sham group undergoes the same surgical procedures, except the suture underneath the LAD is left untied. In another series of experiment, arrhythmia is induced by Bay K8644, an L-type calcium channel agonist, at a dose of 0.1 mg/kg given i.v. into the FV. Verapamil (1 mg/kg) is administered 10 min prior to Bay K8644. All injections are performed within 30 sec |
| References | Drug Metab Pharmacokinet. 2013;28(6):468-74; PLoS One. 2013 Aug 12;8(8):e71567. |
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