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Aminooxy-PEG3-azide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Aminooxy-PEG3-azide图片
CAS NO:1306615-51-9
包装:100mg
市场价:5544元

产品介绍
Aminooxy-PEG3-azide 是一种不可降解 (non-cleavable) 的含 3 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。Aminooxy-PEG3-azide 也是一种 PROTAC linker，属于 PEG 类，可用于合成 PROTAC 分子。
Cas No.1306615-51-9
分子式C8H18N4O4
分子量234.25
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Aminooxy-PEG3-azide is a non-cleavable 3 unit PEGADC linkerused in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-C2-PEG3-azide is also a PEG-basedPROTAC linkerthat can be used in the synthesis of PROTACs[2].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[1]. Chanhyuk KIM, et al. Optimized chimeric receptor t cell switches and uses thereof. WO2016168766A1.
[2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.