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Thalidomide-O-PEG4-azide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Thalidomide-O-PEG4-azide图片
CAS NO:2380318-57-8
包装与价格：
包装价格(元)
100mg电议
250mg电议

产品介绍
Thalidomide-O-PEG4-azide 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Thalidomide 的 cereblon 配体和 1 个 linker。
Cas No.2380318-57-8
分子式C23H29N5O9
分子量519.5
溶解度DMSO : 250 mg/mL (481.23 mM; Need ultrasonic)
储存条件Store at -20°C, away from moisture
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562