| CAS NO: | 2093416-32-9 |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 250mg | 电议 |
| Cas No. | 2093416-32-9 |
| 别名 | Thalidomide-NH-PEG2-C2-NH2 |
| 分子式 | C19H24N4O6 |
| 分子量 | 404.42 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Thalidomide-PEG2-C2-NH2 is a synthesizedE3 ligase ligand-linker conjugatethat incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. [1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163. |
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