JQKD-82(PCK-82)

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JQKD-82(PCK-82)

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	2410512-38-6
规格:	≥98%

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议

产品介绍

理化性质和储存条件

Molecular Formula: C27H40N4O5;

Molecular Weight 500.63

Synonym: PCK 82;JQKD82 HCl; JQKD 82; PCK82; JQKD82; JQKD82 hydrochloride; JQKD-82; PCK-82;

In Vitro	JQKD82 (0.3 μM; 24 hours) causes an increase in the global H3K4me3 level of MM.1S cells[1]. JQKD82 (0.1-10 μM; day 1-day 5) inhibits the growth of MM.1S cells in a dose- and time-dependent manner. JQKD82 is potent at eliciting growth suppression in MM.1S cells (IC50=0.42 μM)[1]. JQKD82 (1 μM; 24 hours) induces G1 cell-cycle arrest by 48 hours in MM.1S and MOLP-8 cells[1].
In Vivo	JQKD82 (50-75 mg/kg; i.p.; twice a day for 3 weeks) has anti-multiple myeloma activity[1]. JQKD82 displayed an increase in H3K4me3 levels and results in a dramatic reduction of MYC immuno-staining in vivo[1]. Animal Model: Six-week-old female NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice (bearing MOLP-8 TurboGFP-Luc cells)[1] Dosage: 50 mg/kg, 75 mg/kg Administration: i.p.; twice a day for 3 weeks Result: Significantly reduced tumor burden

In Vitro

JQKD82 (0.3 μM; 24 hours) causes an increase in the global H3K4me3 level of MM.1S cells[1]. JQKD82 (0.1-10 μM; day 1-day 5) inhibits the growth of MM.1S cells in a dose- and time-dependent manner. JQKD82 is potent at eliciting growth suppression in MM.1S cells (IC50=0.42 μM)[1]. JQKD82 (1 μM; 24 hours) induces G1 cell-cycle arrest by 48 hours in MM.1S and MOLP-8 cells[1].

In Vivo

JQKD82 (50-75 mg/kg; i.p.; twice a day for 3 weeks) has anti-multiple myeloma activity[1]. JQKD82 displayed an increase in H3K4me3 levels and results in a dramatic reduction of MYC immuno-staining in vivo[1]. Animal Model: Six-week-old female NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice (bearing MOLP-8 TurboGFP-Luc cells)[1] Dosage: 50 mg/kg, 75 mg/kg Administration: i.p.; twice a day for 3 weeks Result: Significantly reduced tumor burden