您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > N-Boc-PEG9-alcohol
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
N-Boc-PEG9-alcohol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N-Boc-PEG9-alcohol图片
CAS NO:2112731-44-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
1g电议
5g电议

产品介绍
N-Boc-PEG9-alcohol 是一种 PROTAC 连接桥,属于 PEG 类和 Alkyl/ether 类。N-Boc-PEG9-alcohol 可用于合成一系列 PROTAC 分子。N-Boc-PEG9-alcohol 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体药物结合物 (ADCs) 的合成。
Cas No.2112731-44-7
分子式C23H47NO11
分子量513.62
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

N-Boc-PEG9-alcohol is a PEG/Alkyl/ether-basedPROTAC linkercan be used in the synthesis of PROTACs. N-Boc-PEG9-alcohol is a cleavableADC linkerused in the synthesis of antibody-drug conjugates (ADCs)[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[1]. Nello Mainolfi, wt al. Irak degraders and uses thereof. US20190192668A1.