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SM-6586
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SM-6586图片
CAS NO:103898-38-0
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
SM-6586是一种calciumchannel的拮抗剂,同时能够抑制Na+/H+和Na+/Ca2+exchangetransport,主要用于研究脑血管疾病和高血压等疾病。
Cas No.103898-38-0
Canonical SMILESO=C(C1=C(C)NC(C)=C(C2=NC(CN(C)CC3=CC=CC=C3)=NO2)C1C4=CC=CC([N+]([O-])=O)=C4)OC
分子式C26H27N5O5
分子量489.52
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SM-6586 is a calcium channel antagonist and inhibitor of Na+/H+ and Na+/Ca2+ exchange transport, potentially for the treatment of cerebrovasular diseases and hypertension.

In SM-6586-treated spontaneously hypertensive rats, the survival rate after bilateral common carotid artery ligation is higher, the brain water content is lower, and the ATP level is higher and lactate level. In focal ischemia models, the SM-treated group shows a reduction of T1 relaxation time. The brain water content is significantly decreased in the SM-treated group[1].

[1]. Kashiwagi F, et al. Effect of a new calcium antagonist (SM-6586) on experimental cerebral ischemia. Acta Neurochir Suppl (Wien). 1994;60:289-92.