| CAS NO: | 2260670-15-1 |
| 包装 | 价格(元) |
| 500μg | 电议 |
| 1mg | 电议 |
| Cas No. | 2260670-15-1 |
| 别名 | 鞘氨醇-1-磷酸酯-D7(D18:1),S1P-d7 (d18:1), Sphingosine-1-Phosphoric Acid-d7 |
| 化学名 | (2S,3R,4E)-2-amino-4-octadecene-16,16,17,17,18,18,18-d7-1,3-diol, 1-(dihydrogen phosphate) |
| Canonical SMILES | O[C@H](/C=C/CCCCCCCCCCC([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])[C@@H](N)COP(O)(O)=O |
| 分子式 | C18H31D7NO5P |
| 分子量 | 386.5 |
| 溶解度 | 0.3 M NaOH: 4 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Sphingosine-1-phosphate-d7 is intended for use as an internal standard for the quantification of sphingosine-1-phosphate by GC- or LC-MS. S1P is the product of phosphorylation of sphingosine by sphingosine kinase that is secreted from cells and acts as an agonist at S1P receptors.[1] It increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi proteins, when used at a concentration of 200 nM, as well as in TAg-Jurkat cells expressing S1P2 and S1P3 receptors (EC50s = 8 and 11 nM, respectively).[2] Intra- and extracellular levels of S1P vary spatially allowing it to function as an autocrine or paracrine factor, respectively, and dysregulation of S1P levels are associated with various disease states, such as inflammation and autoimmunity.[3] S1P has a wide variety of effects, including an involvement in cell growth, angiogenesis, immunity, and neuroprotection. Reference: |
m.cnreagent.com