| CAS NO: | 193222-34-3 |
| 包装 | 价格(元) |
| 500μg | 电议 |
| 1mg | 电议 |
| Cas No. | 193222-34-3 |
| 别名 | 1-deoxySO, 4E-1-Deoxysphingosine (m18:1) |
| 化学名 | 2S-amino-4E-octadecen-3R-ol |
| Canonical SMILES | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)C |
| 分子式 | C18H37NO |
| 分子量 | 283.5 |
| 溶解度 | DMF: 10 mg/ml,DMSO: 2 mg/ml,Ethanol: miscible |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 1-Deoxysphingosine (m18:1(4E)) is an atypical sphingolipid that contains a double bond at the 4E native position and is formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2 Plasma levels of 1-deoxysphingosine (m18:1(4E)) are increased in patients with chronic idiopathic axonal neuropathy (CIAP) and diabetic distal symmetrical polyneuropathy (DSPN).3 |1. Steiner, R., Saied, E.M., Othman, A., et al. Elucidating the chemical structure of native 1-deoxysphingosine. J. Lipid Res. 57(7), 1194-1203 (2016).|2. Alecu, I., Othman, A., Penno, A., et al. Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway. J. Lipid Res. 58(1), 60-71 (2017).|3. Hube, L., Dohrn, M.F., Karsai, G., et al. Metabolic syndrome, neurotoxic 1-deoxysphingolipids and nervous tissue inflammation in chronic idiopathic axonal polyneuropathy (CIAP). PLoS One 12(1):e0170583, (2017). |
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