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NS 3861
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NS 3861图片
CAS NO:216853-60-0
包装与价格:
包装价格(元)
5mg电议
25mg电议

产品介绍
NS 3861 是烟碱型乙酰胆碱受体 (nAChRs) 的激动剂,并以高亲和力与异聚体 α3β4 nAChR 结合。
Cas No.216853-60-0
Canonical SMILESCN1C2CCC1CC(C3=C(Br)C=CS3)=C2.OC(/C=C/C(O)=O)=O
分子式C12H14BrNS.C4H4O4
分子量400.29
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

α3β2 full agonist (EC50 = 1.6 μM). Also α3β4 partial agonist (EC50 = 1 μM). Exhibits minimal activity at α4β2 and α4β4. Displays high affinity for α3β4, α4β4, α3β2 and α4β2 (Ki values are 0.62, 7.8, 25 and 55 nM respectively).

Harpsøe et al (2013) Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors. J.Biol.Chem. 288 2559 PMID:23229547