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Pralidoxime iodide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pralidoxime iodide图片
CAS NO:94-63-3
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
25mg电议
100mg电议
250mg电议

产品介绍
Pralidoxime iodide 是乙酰胆碱酯酶 (AChE) 的活化剂。Pralidoxime iodide 能激活神经毒剂,抑制乙酰胆碱酯酶的活性,其途径是通过结合神经毒剂磷中心的肟部分直接亲核攻击。Pralidoxime iodide 是有机磷中毒的解毒剂。
Cas No.94-63-3
别名碘解磷定
Canonical SMILESC[N+]1=CC=CC=C1/C=N/O.[I-]
分子式C7H9IN2O
分子量264.06
溶解度DMSO: 250 mg/mL (946.75 mM)
储存条件Store at -20°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Pralidoxime iodide is a reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent, which inhibits AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning[1][2].

[1]. Cadieux CL, et al. Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. Chem Biol Interact. 2016;259(Pt B):133‐141. [2]. Eyer P, Buckley N. Pralidoxime for organophosphate poisoning. Lancet. 2006;368(9553):2110‐2111. [3]. HouzÉ P, et al. High Dose of Pralidoxime Reverses Paraoxon-Induced Respiratory Toxicity in Mice. Turk J Anaesthesiol Reanim. 2018;46(2):131‐138.