Cangrelor（钠盐）是一种三磷酸腺苷类似物，是一种可逆的选择性血小板 P2Y12 拮抗剂，具有迅速而有效的抗血小板作用。
| Cas No. | 163706-36-3 |
| 别名 | 坎格雷洛四钠盐,AR-C69931MX tetrasodium |
| Canonical SMILES | O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=C(SCCC(F)(F)F)N=C3NCCSC)O[C@@H]1COP(OP(C(Cl)(Cl)P([O-])([O-])=O)([O-])=O)([O-])=O.[Na+].[Na+].[Na+].[Na+] |
| 分子式 | C17H21Cl2F3N5O12P3S2•4Na |
| 分子量 | 864.3 |
| 溶解度 | Water: Soluble |
| 储存条件 | 4°C, away from moisture and light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Cangrelor is an ATP analog that inhibits platelet aggregation (IC50 = 0.4 nM). It is a reversible competitive antagonist of the platelet purinergic P2Y12 receptor. Pretreatment with cangrelor significantly reduces blood clotting induced by ADP in a mouse model of pulmonary thromboembolism. Formulations containing cangrelor have been used to prevent blood clotting in at-risk patients. |
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