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Adenosine deaminase
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:9026-93-1
包装:1mg (150u/mg protein)
市场价:2520元

产品介绍
腺苷脱氨酶是一种酶,可催化腺苷和 2'-脱氧腺苷不可逆地分别脱氨为肌苷和 2'-脱氧肌苷。
Cas No.9026-93-1
别名腺苷脫氨酶
Canonical SMILES[Adenosine deaminase]
分子量~33 kDa (SDS-PAGE)
溶解度Buffered aqueous glycerol solution
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Adenosine deaminase is an enzyme that catalyzes the irreversible deamination of adenosine and 2’-deoxyadenosine to inosine and 2’-deoxyinosine, respectively.

Adenosine deaminase (ADA; EC 3.5.4.4) catalyzes the irreversible deamination of adenosine and 2′-deoxyadenosine to inosine and 2′-deoxyinosine, respectively. Adenosine deaminase is implicated in purine metabolism and distributed in most mammalian tissues. Genetic Adenosine deaminase deficiency results in lymphopenia and severe combined immunodeficiency disease by decreasing the differentiation and maturation of lymphoid cells[1]. Adenosine deaminase is a signaling molecule related to the activation of T lympho-cytes, making it a useful inflammation marker, especially for menin-gitis and tuberculous pleuritis[2].

[1]. Tian X, et al. Probing inhibition mechanisms of adenosine deaminase by using molecular dynamics simulations. PLoS One. 2018 Nov 16;13(11):e0207234.
[2]. Silva Dalsasso Joaquim L, et al. Analytical validation of an in-house method for adenosine deaminase determination. J Clin Lab Anal. 2018 Nov 29:e22823.