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Kif15-IN-2
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Kif15-IN-2图片
CAS NO:672926-33-9
包装与价格：
包装价格(元)
2mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
Kif15-IN-2 是有丝分裂驱动蛋白 Kif15 的抑制剂，用于细胞增殖性疾病的研究。
Cas No.672926-33-9
别名(ALPHAS)-1,4-二氢-ALPHA-异丙基-N-[4-甲基-5-(5-甲基-1,3,4-恶二唑-2-基)-2-噻唑基]-2,4-二氧代-3(2H)-喹唑啉乙酰胺
化学名(S,Z)-2-(2-hydroxy-4-oxoquinazolin-3(4H)-yl)-3-methyl-N-(4-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)thiazol-2-yl)butanimidic acid
Canonical SMILESCC([C@@](N1C(C2=CC=CC=C2N=C1O)=O)([H])/C(O)=N/C3=NC(C)=C(S3)C4=NN=C(O4)C)C
分子式C20H20N6O4S
分子量440.48
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Kif15-IN-2, a potent Kif15 kinesin inhibitor; inhibits cellular proliferation in various tumor cell lines [1].

Kif15,also known as Kinesin-12 and HKLP2, is a motor protein expressed in all cells during mitosis and in postmitotic neurons undergoing axon growth [2]. Kif15 is a kinesin-related protein whose mitotic homologues are believed to crosslink and immobilize spindle microtubules.KIF15 is involved in maintainingbipolar microtubulespindle apparatusin dividing cells and shares redundant functions withKIF11 [3].

References:
[1]. Preparation of quinazolinediones as Kif15 kinesin inhibitors for treating cellular proliferative disorders. Pat. Appl. Publ. (2004), US 20040053948 A1 20040318.
[2].  Buster D W, Baird D H, Yu W, et al. Expression of the mitotic kinesin Kif15 in postmitotic neurons: implications for neuronal migration and development[J]. Journal of neurocytology, 2003, 32(1): 79-96.
[3].  Vanneste D, Takagi M, Imamoto N, et al. The role of Hklp2 in the stabilization and maintenance of spindle bipolarity[J]. Current Biology, 2009, 19(20): 1712-1717.