Antitrypanosomal agent 1

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	75144-12-6
包装:	100mg
市场价:	855元

产品介绍

Antitrypanosomal agent 1 是一种有效的，选择性锥虫硫磷还原酶 (trypanothione reductase) 抑制剂，IC50 为 3.3 μM。Antitrypanosomal agent 1 抑制谷胱甘肽还原酶 (glutathione reductase)，IC50 为 64.8 μM；抑制布氏锥虫，EC50 为 1 μM。Antitrypanosomal agent 1 具有抗锥虫活性。

Cas No.	75144-12-6
别名	1-(3,4-二氯苯基)-3-(二甲基氨基)丙-1-酮盐酸盐
Canonical SMILES	O=C(C1=CC=C(Cl)C(Cl)=C1)CCN(C)C.[H]Cl
分子式	C₁₁H₁₄Cl₃NO
分子量	282.59
溶解度	DMSO: 25 mg/mL (88.47 mM); Water: 10 mg/mL (35.39 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor with an IC50 of 3.3 μM. Antitrypanosomal agent 1 inhibits glutathione reductase (GR) (IC50=64.8 μM) and T. brucei (EC50=1 μM). Antitrypanosomal agent 1 has anti-trypanosomal activity[1]. [1]. Martyn DC, et al. High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1280-3.