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L67
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L67图片
CAS NO:325970-71-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
L67 (DNA Ligase Inhibitor) 是一种竞争性 DNA 连接酶抑制剂,可有效抑制 DNA 连接酶 I/III(IC50 均为 10 μM)。 L67(DNA 连接酶抑制剂)可通过降低线粒体 DNA 水平和增加线粒体产生的 ROS 水平来引起核 DNA 损伤。 L67 (DNA Ligase Inhibitor) 还激活癌细胞中 Caspase 1 依赖性凋亡通路,可用于癌症研究。
Cas No.325970-71-6
别名DNA Ligase Inhibitor
化学名N-(3,5-dibromo-4-methylphenyl)-glycine, 2-[(2-hydroxy-5-nitrophenyl)methylene]hydrazide
Canonical SMILESOC1=CC=C([N+]([O-])=O)C=C1/C=N/NC(CNC2=CC(Br)=C(C)C(Br)=C2)=O
分子式C16H14Br2N4O4
分子量486.1
溶解度DMF: 10 mg/ml,DMSO: 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述 L67 is a competitive inhibitor of DNA ligases I and III (IC50s = 10 and 10 uM for human DNA ligase I and human ligase IIIβ). It blocks DNA binding (Ki = 10 uM), increasing the cytotoxicity of DNA-damaging agents. It also inhibits mitochondrial DNA ligase IIIα and induces the production of reactive oxygen species (ROS) and apoptosis in cancerous, but not non-malignant, cells. It does not inhibit DNA ligase IV or T4 DNA ligase at concentrations up to 100 uM.