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PD 407824
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PD 407824图片
CAS NO:622864-54-4
包装与价格:
包装价格(元)
10mM 1 mL in DMSO电议
1mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
PD 407824 是一种检查点激酶 Chk1 和 WEE1 抑制剂,IC50 分别为 47 和 97 nM。
Cas No.622864-54-4
化学名9-hydroxy-4-phenyl-pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
Canonical SMILESO=C1NC(C2=C1C(C(C=C(O)C=C3)=C3N4)=C4C=C2C5=CC=CC=C5)=O
分子式C20H12N2O3
分子量328.3
溶解度DMSO: 250 mg/mL (761.45 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述 PD 407824 is an inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s = 47 and 97 nM, respectively). It is selective for Chk1 and WEE1 over PKC (IC50 = 3.4 uM), Cdk4 (IC50 = 3.75 uM), as well as c-Src and the PDGF and FGF receptors (IC50s = >50 uM for all), and other Cdks (IC50s = >50 uM). PD 407824 sensitizes SK-OV-3 and OVCAR-3 ovarian cancer cells, as well as cisplatin-resistant A2780cis cells, to cisplatin when used at a concentration of 0.5 uM. It also sensitizes C2C12 myoblasts to bone morphogenic protein 4 (BMP4) and, when used in combination with BMP4, inhibits myotube formation and induces myoblasts to differentiate into mature osteoblasts. PD 407824, in combination with BMP4, induces human embryonic stem cells to differentiate into cells with mesoderm or cytotrophoblast stem cell lineages.