您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > MST-312
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
MST-312
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MST-312图片
CAS NO:368449-04-1
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
DB2115 (tertahydrochloride) 是一种有效的骨髓主调节剂 PU.1 抑制剂。 DB2115 (tertahydrochloride) 具有研究癌症的潜力,包括白血病等血液系统癌症以及与 PU 相关的其他疾病。 1 功能障碍(摘自专利WO2017223260A1,化合物DB2115)。
Cas No.368449-04-1
别名Telomerase Inhibitor IX
化学名N,N'-1,3-phenylenebis[2,3-dihydroxy-benzamide
Canonical SMILESOC1=C(O)C(C(NC2=CC=CC(NC(C3=C(O)C(O)=CC=C3)=O)=C2)=O)=CC=C1
分子式C20H16N2O6
分子量380.4
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:40): 0.025 mg/ml,Ethanol: 0.2 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述 MST312 is a telomerase inhibitor (IC50 = 0.67 μM in a TRAP assay). It is selective for telomerase over DNA polymerase when used at concentrations up to 3 μM. MST312 inhibits growth of U937 cells via telomere shortening (GI50 = 1.7 μM). It reduces cell number and expression of the proliferation marker MIB-1 as well as increases DNA damage in primary pediatric ependymoma tumor cells. MST312 decreases survival of H460 and H1299 non-small cell lung cancer (NSCLC) cells in a dose-dependent manner with a greater effect on the aldehyde dehydrogenase positive (ALDH+) cancer stem cell population. In vivo, MST312 (40 mg/kg) reduces tumor size by 70% in an H460 mouse xenograft model. MST312 also inhibits replication of herpes simplex virus 2 (HSV-2) and a clinical isolate of HSV-1 and decreases accumulation of early and late viral proteins in HEp-2 cells infected with HSV-1.