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Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)图片
CAS NO:39916-28-4
包装与价格：
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
An inducer of ferroptosis
Cas No.39916-28-4
Canonical SMILES[Cl-][Fe+3]123[N](C4=CC=CC=C4[N]2=CC5=CC=CC=C5[O-]3)=CC6=CC=CC=C6[O-]1
分子式C20H14ClFeN2O2
分子量405.6
溶解度DMF: 20 mg/ml,DMSO: 14 mg/ml,Ethanol: 0.3 mg/ml,PBS (pH 7.2): Partially soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) is an inducer of ferroptosis.1 It induces ferroptosis, but not apoptosis or necroptosis, in NB1 cancer cells when used at a concentration of 3 μM.1 Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) inhibits proliferation of BJAB, NALM-6, Jurkat, MelHO, and MCF-7 cancer cells (IC50s = 0.07, 2.5, 1.5, 3, and 5 μM, respectively), as well as NALM-6 cells resistant to daunorubicin and vincristine when used at concentrations ranging from 0.04 to 0.125 μM.2

|1. Sagasser, J., Ma, B., Baecker, D., et al. A new approach in cancer treatment: Discovery of chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) complexes as ferroptosis inducers. J. Med. Chem. 62(17), 8053-8061 (2019).|2. Lee, S.-Y., Hille, A., Kitanovic, I., et al. [FeIII(salophene)Cl], a potent iron salophene complex overcomes multiple drug resistance in lymphoma and leukemia cells. Leuk. Res. 35(3), 387-393 (2011).