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Tranexamic Acid-13C2,15N
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tranexamic Acid-13C2,15N图片
CAS NO:1292837-95-6
包装:1mg
市场价:5972元

产品介绍
An internal standard for the quantification of tranexamic acid
Cas No.1292837-95-6
Canonical SMILESO[13C]([C@H]1CC[C@H]([13CH2][15NH2])CC1)=O
分子式C6[13C2]H15[15N]O2
分子量160.2
溶解度Water: slightly soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tranexamic acid 13C2,15N is intended for use as an internal standard for the quantification of tranexamic acid by GC- or LC-MS. Tranexamic acid is an inhibitor of fibrinolysis that inhibits the interaction of plasmin with fibrin (IC50 = 3.1 μM in isolated human plasma).1 It reduces increases in the expression of the profibrogenic genes Timp1 and Col1a1, but not Itgb6, Tgfβ1, or Tgfβ2, and increases in hepatic protein levels of cytokeratin 19 (CK19) and type I collagen induced by α-naphthylisothiocyanate (AINT) after 28 days in a mouse model of chronic bile duct injury.2

|1. Bostr•m, J., Grant, J.A., Fjellstr•m, O., et al. Potent fibrinolysis inhibitor discovered by shape and electrostatic complementarity to the drug tranexamic acid. J. Med. Chem. 56(8), 3273-3280 (2013).|2. Joshi, N., Kopec, A.K., Towery, K., et al. The antifibrinolytic drug tranexamic acid reduces liver injury and fibrosis in a mouse model of chronic bile duct injury. J. Pharmacol. Exp. Ther. 349(3), 383-392 (2014).