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Tolnaftate-d7
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tolnaftate-d7图片
CAS NO:1329835-64-4
包装与价格:
包装价格(元)
500μg电议
1mg电议

产品介绍
An internal standard for the quantification of tolnaftate
Cas No.1329835-64-4
别名托萘酯 D7
Canonical SMILESCN(C1=CC(C)=CC=C1)C(OC2=C([2H])C3=C([2H])C([2H])=C([2H])C([2H])=C3C([2H])=C2[2H])=S
分子式C19H10D7NOS
分子量314.5
溶解度Acetonitrile: soluble,DMSO: soluble,Methanol: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tolnaftate-d7 is intended for use as an internal standard for the quantification of tolnaftate by GC- or LC-MS. Tolnaftate is an antifungal compound used in certain formulations as a topical treatment of infections of the skin.1,2 It inhibits the in vitro growth of clinical isolates of dermatophyte species T. rubrum, T. mentagraphytes, T. verrucosum, E. floccosum, and M. canis with minimal inhibitory concentration 50 (MIC50) values of 0.05, 0.1, 0.006, 0.05, and 0.05 μg/ml, respectively.3 It also exhibits high potency against a wide range of pathogenic yeast and filamentous fungi grown in dextrose broth.4 The predicted target of tolnaftate is squalene epoxidase.5

|1. Adam, J.E., and Craig, G.E. Tolnaftate (tinactin), a new topical antifungal agent. Can. Med. Assoc. J. 93(19), 1004-1005 (1965).|2. Robinson, H.M., Jr., and Raskin, J. Tolnaftate therapy of mycotic infections. J. Invest. Dermatol. 42, 185-187 (1964).|3. Petranyi, G., Meingassner, J.G., and Mieth, H. Antifungal activity of the allylamine derivative terbinafine in vitro. Antimicrob. Agents Chemother. 31(9), 1365-1368 (1987).|4. Waitz, J.A., Moss, E.L., and Weinstein, M.J. Chemotherapeutic evaluation of clotrimazole [Bay b 5097, 1 (o-chloro-α-α-diphenylbenzyl) imidazole]. Appl. Microbiol. 22(5), 891-898 (1971).|5. Gregori-PuigjanÉ, E., Setola, V., Hert, J., et al. Identifying mechanism-of-action targets for drugs and probes. Proc. Natl. Acad. Sci. USA 109(28), 11178-11183 (2012).