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HPOB
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
HPOB图片
CAS NO:1429651-50-2
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
HPOB 是一种高效、选择性的 HDAC6 抑制剂,IC50 为 56 nM。 HPOB 对其他 HDAC 的效力降低了 30 倍以上。 HPOB 可增强 DNA 破坏性抗癌剂在转化细胞而非正常细胞中的有效性。 HPOB 不会阻断 HDAC6 的泛素结合活性。
Cas No.1429651-50-2
化学名N-hydroxy-4-(2-((2-hydroxyethyl)(phenyl)amino)-2-oxoethyl)benzamide
Canonical SMILESOCCN(C(CC1=CC=C(C(NO)=O)C=C1)=O)C2=CC=CC=C2
分子式C17H18N2O4
分子量314.34
溶解度≥ 31.4mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

HPOB is a highly potent and selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 56nM, >30 fold less potent against other HDACs. [1]
HDAC6 is one of the eleven human zinc-dependent HDACs with two catalytic domains and one ubiquitin-binding domain at the C-terminal. It exhibits various biological functions including regulation of microtubule dynamics and degradation of misfolded proteins. It involves in many cellular pathways related to normal and tumor cell growth, migration and death. [1]
In normal HFS and transformed LNCaP cells, HPOB inhibited cell growth but not viability, induced acetylation of α-Tubulin, but not histones. HPOB enhanced etoposide-, doxorubicin-, and SAHA-induced cell death in transformed cell but not in normal cell. HPOB enhanced the effectives of anticancer drugs via apoptotic pathway and activated DNA damage response in transformed cell. [1]
HPOB is well-tolerated in mice carrying human prostate cancer CWR22 xenograft and enhances cytotoxicity effects of anticancer drug SAHA in these animals. [1]
References:
1.  Lee JH, Mahendran A, Yao Y, Ngo L, Venta-Perez G, Choy ML, Kim N, Ham WS, Breslow R, Marks PA. Development of a histone deacetylase 6 inhibitor and its
biological effects. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15704-9.