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EX-527 R-enantiomer
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
EX-527 R-enantiomer图片
CAS NO:848193-69-1
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
EX-527 R-对映异构体 ((R)-EX-527) 是 Selisstat 的 R-对映异构体。 Selisistat (EX-527) 是一种有效的选择性 SIRT1 抑制剂,IC50 为 98 nM。
Cas No.848193-69-1
别名(R)-EX-527
化学名(R)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Canonical SMILESClC1=CC2=C(NC3=C2CCC[C@H]3C(N)=O)C=C1
分子式C13H13ClN2O
分子量248.71
溶解度Soluble in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Selisistat R-enantiomer (EX-527 R-enantiomer) is much less active R-enantiomer of Selisistat, with an IC50 of >100 μM for SIRT1.

References:
[1]. Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54.