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Garcinol
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Garcinol图片
CAS NO:78824-30-3
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
Garcinol 是一种从 Garcinia indica 中提取的聚异戊二烯二苯甲酮，对乙酰胆碱酯酶 (AChE) 和丁酰胆碱酯酶 (BChE) 具有抗胆碱酯酶特性，IC50 分别为 0.66 μM 和 7.39 μM 。
Cas No.78824-30-3
别名山竹子素
化学名(1R,5R,7R)-3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-5-((S)-5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl)-1,7-bis(3-methylbut-2-en-1-yl)bicyclo[3.3.1]non-3-ene-2,9-dione
Canonical SMILESO=C1[C@](C(O)=C2C(C3=CC(O)=C(O)C=C3)=O)(C[C@H](C/C=C(C)/C)C(C)=C)C[C@@H](C/C=C(C)/C)C(C)(C)[C@@]1(C/C=C(C)/C)C2=O
分子式C38H50O6
分子量602.8
溶解度20mg/mL in ethanol, 25mg/mL in DMSO, 25mg/mL in DMF
储存条件Store at -20℃,protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
文献引用
产品描述

Garcinol is an inhibitor of the histone acetyltransferases (HATs) p300 and PCAF (IC50 = 7 and 5 μM, respectively).[1] It also inhibits the HAT GCN5 in Cryptococcus neoformans, inducing temperature sensitivity and impairing growth.[2] A polyisoprenylated benzophenone isolated from Garcinia indica, garcinol promotes neurogenesis and ex vivo expansion of human hematopoietic stem cells.[3],[4] Moreover, it induces apoptosis in several types of cancer cells and has anti-inflammatory actions.[5],[6]

Reference:
[1]. Balasubramanyam, K., Altaf, M., Varier, R.A., et al. Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. The Journal of Biological Chemisty 279(6), 33716-33726 (2004).
[2]. O'Meara, T.R., Hay, C., Price, M.S., et al. Cryptococcus neoformans histone acetyltransferase Gcn5 regulates fungal adaptation to the host. Eukaryot.Cell 9(8), 1193-1202 (2010).
[3]. Weng, M.S., Liao, C.H., Yu, S.Y., et al. Garcinol promotes neurogenesis in rat cortical progenitor cells through the duration of extracellular signal-regulated kinase signaling. Journal of Agricultural and Food Chemistry 59, 1031-1040 (2011).
[4]. Nishino, T., Wang, C., Mochizuki-Kashio, M., et al. Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase. PLoS One 6(9), 1-9 (2011).
[5]. Prasad, S., Ravindran, J., Sung, B., et al. Garcinol potentiates TRAIL-induced apoptosis through modulation of death receptors and antiapoptotic proteins. Molecular Cancer Therapeutics 9(4), 856-868 (2010).
[6]. Koeberle, A., Northoff, H., and Werz, O. Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol. Biochemical Pharmacology 77(9), 1513-1521 (2009).