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WDR5 0103
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
WDR5 0103图片
CAS NO:890190-22-4
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
10mg电议
50mg电议

产品介绍
WDR5 0103 是一种有效的选择性 WD 重复蛋白 5 (WDR5) 拮抗剂,Kd 为 450 nM。
Cas No.890190-22-4
别名WD-Repeat Protein 5-0103
化学名methyl 3-(3-methoxybenzamido)-4-(4-methylpiperazin-1-yl)benzoate
Canonical SMILESCOC(C1=CC(NC(C2=CC=CC(OC)=C2)=O)=C(N3CCN(C)CC3)C=C1)=O
分子式C21H25N3O4
分子量383.44
溶解度≥ 12.5mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

WDR5-0103 is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist with Kd of 450 nM.IC50 value: 450 nM (Kd)Target: WDR5in vitro: WDR5-0103 inhibits MLL catalytic activity with an IC50 value of 39±10 μM. An increase in MLL complex concentration resulted in proportional increase in IC50 values for WDR5-0103 (83±10 and 280±12 μM at concentrations of 500 and 1000 nM of the core trimeric MLL complex respectively). These data are consistent with a mechanism of action in which WDR5-0103 antagonizes the interaction of WDR5 with MLL by competing with MLL for their mutual binding site on WDR5.

References:
[1]. Senisterra G, et al. Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem J. 2013 Jan 1;449(1):151-159.