| CAS NO: | 380537-35-9 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
SI-2 is an inhibitor of steroid receptor coactivator 3 (SRC-3).
| Cas No. | 380537-35-9 |
| 化学名 | (1E)-1-(2-pyridinyl)-ethanone-2-(1-methyl-1H-benzimidazol-2-yl)hydrazone |
| Canonical SMILES | C/C(C1=NC=CC=C1)=N\NC2=NC3=C(C=CC=C3)N2C |
| 分子式 | C15H15N5 |
| 分子量 | 265.3 |
| 溶解度 | 20mg/mL in ethanol, 30mg/mL in DMSO or DMF |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | SI-2 is an inhibitor of steroid receptor coactivator 3 (SRC-3). It has been shown to selectively reduce the transcriptional activities and the protein concentrations of SRC-3 in cells through direct physical interactions with SRC-3.1 SI-2 induces death in various breast cancer cells with IC50 values of 3-20 nM without affecting normal cell viability.[1] At 2 mg/kg, SI-2 can also inhibit primary tumor growth and reduce SRC-3 protein levels in an MDA-MB-468 breast cancer mouse model.[1] Reference: |
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