| Cas No. | 6377-18-0 |
| 别名 | 教酒菌素 |
| 化学名 | 10-[[6-deoxy-2-O-(6-deoxy-3-O-methyl-α-D-galactopyranosyl)-β-D-galactopyranosyl]oxy]-6-hydroxy-1-methyl-benzo[h][1]benzopyrano[5,4,3-cde][1]benzopyran-5,12-dione |
| Canonical SMILES | OC1=C(C(OC2=C3C(C(O4)=O)=C(C)C=C2)=O)C3=C4C5=C1C=CC=C5O[C@@H]6O[C@H](C)[C@H](O)[C@H](O)[C@H]6O[C@]7([H])[C@H](O)[C@@H](OC)[C@@H](O)[C@@H](C)O7 |
| 分子式 | C32H32O14 |
| 分子量 | 640.6 |
| 溶解度 | Acetone: soluble,DMSO: 10 mg/ml,Methanol: slightly soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Chartreusin is an antibiotic originally isolated from S. chartreusis with diverse biological activities. It inhibits growth of S. aureus, B. subtilis, M. luteus, M. flavus, B. fragilis, C. difficile, C. perfringens, and P. acnes (MICs = 0.4-12.5 μg/ml). Chartreusin binds to DNA and induces electrophoretic shifts in both supercoiled and nicked plasmid DNA. It also inhibits strand-passing activity of topoisomerase II in a P4 unknotting assay. Chartreusin inhibits protein synthesis in chick embryo fibroblasts (CEFs) and mouse fibroblast 3T6 cells (IC50s = 7 and 70 μM, respectively). It is cytotoxic to human lung carcinoma A549 cells in vitro (IC50 = 95 nM) and increases median survival in P388 leukemia and B16 melanoma mouse tumor models when administered at a dose of 10 mg/kg per day. |
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