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N-Acetylprocainamide(Acecainide)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N-Acetylprocainamide(Acecainide)图片
CAS NO:32795-44-1
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
100mg电议

产品介绍
N-Acetylprocainamide (Accecainide) 是一种 III 类抗心律失常药,可阻断 K+ 通道。
Cas No.32795-44-1
别名N-乙酰普鲁卡因胺; Acecainide; NAPA
Canonical SMILESO=C(NCCN(CC)CC)C1=CC=C(NC(C)=O)C=C1
分子式C15H23N3O2
分子量277.36
溶解度DMSO : ≥ 150 mg/mL (540.81 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

N-Acetylprocainamide is a class III antiarrhythmic, which blocks K+ channels.

N-Acetylprocainamide is a K+ blocker. N-Acetylprocainamide decreases the tensions induced by K+ and methacholine. The pIC50 values for N-acetylprocainamide against the contractions induced by 0.3 and 1 μM methacholine are 2.80 ± 0.03 and 2.65 ± 0.02, respectively. And such a relaxant effect of N-Acetylprocainamide is inhibited by K+ channel blockers[1]. N-Acetylprocainamide shows no effect on Na+ absorption or Cl- secretion[2].

[1]. Nakahara T, et al. Role of K+ channels in N-acetylprocainamide-induced relaxation of bovine tracheal smooth muscle. Eur J Pharmacol. 2001 Mar 9;415(1):73-8. [2]. Plass H, et al. Class I antiarrhythmics inhibit Na+ absorption and Cl- secretion in rabbit descending colon epithelium. Naunyn Schmiedebergs Arch Pharmacol. 2005 Jun;371(6):492-9.