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Tetrabenazine-d6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tetrabenazine-d6图片
CAS NO:1392826-25-3
包装与价格:
包装价格(元)
500 µg电议
1mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Tetrabenazine D6 是氘标记的 Tetrabenazine,它是一种 VMAT 抑制剂,用于治疗多动性运动障碍。
Cas No.1392826-25-3
别名(+)-丁苯那嗪 D6;(+)-丁苯喹嗪 D6;(+)-特苯那嗪 D6;(+)-四苯喹嗪 D6
Canonical SMILESO=C1[C@H](CC(C)C)CN2[C@](C(C=C(OC([2H])([2H])[2H])C(OC([2H])([2H])[2H])=C3)=C3CC2)([H])C1
分子式C19H21D6NO3
分子量323.5
溶解度DMF: 30 mg/ml,DMF:PBS(pH7.2) (1:2): 0.33 mg/ml,DMSO: 25 mg/ml,Ethanol: 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tetrabenazine-d6 is intended for use as an internal standard for the quantification of tetrabenazine by GC- or LC-MS. Tetrabenazine is an inhibitor of vesicular monoamine transporter 2 (VMAT2) that is selective over VMAT1 (Kis = 97 and >20,000 nM, respectively, in a serotonin uptake assay). It dose-dependently reduces levels of the monoamines norepinephrine , dopamine , and serotonin in rat brain and has been used to induce depressive-like behavior in animal models. Tetrabenazine (5 mg/kg) improves performance in balance beam and rotarod tests and prevents decreases in the number of striatal medium spiny neurons (MSNs) in a YAC128 transgenic mouse model of Huntington's disease. Formulations containing tetrabenazine have been used in the treatment of chorea associated with Huntington's disease.