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Endovion
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Endovion图片
CAS NO:265646-85-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍

Endovion(NS3728)是一种阴离子通道抑制剂(如氯离子通道),也是特异性的VRAC/VSOAC阻断剂。Endovion(NS3728)还是一种ANO1抑制剂。

Cas No.265646-85-3
别名NS3728
Canonical SMILESFC(F)(F)C1=CC(C(F)(F)F)=CC(NC(NC2=C(C3=NN=NN3)C=C(Br)C=C2)=O)=C1
分子式C16H9BrF6N6O
分子量495.18
溶解度Water :< 0.1 mg/mL (insoluble)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Endovion (NS3728) is a pharmacological anion channel inhibitor (like chloride channel) and the specific VRAC/VSOAC blocker. Endovion (NS3728) is also an Anoctamin-1 (ANO 1) channel inhibitor[1][2]. Chloride channel, VRAC/VSOAC[1]. ANO1[2].

[1]. S?rensen BH, et al. Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against Cisplatin-induced expression of p53, MDM2, p21Waf1/Cip1, and Caspase-9/-3 activation. Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C857-73. [2]. Sauter DR, et al. ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC). Pflugers Arch. 2015 Jul;467(7):1495-1508.