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Tat-NR2B9c TFA
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Tat-NR2B9c TFA图片
CAS NO:1834571-04-8
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Tat-NR2B9c(TFA)是由20个氨基酸组成的多肽，为PSD-95的抑制剂，对PSD-95d2和PSD-95d1的EC50值分别为6.7nM和670nM。Tat-NR2B9c同时可降低NMDA诱导的p38的活化，具有神经保护作用。
Cas No.1834571-04-8
别名Tat-NR2Bct TFA; NA-1 TFA
Canonical SMILESOC(C(F)(F)F)=O.[YGRKKRRQRRRKLSSIESDV]
分子式C107H189F3N42O32
分子量2632.9
溶解度Water : ≥ 50 mg/mL (18.99 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tat-NR2B9c (TFA) is a 20-aa peptide, which acts as a postsynaptic density-95 (PSD-95) inhibitor, with an EC50 of 6.7 nM for PSD-95d2 (PSD-95 PDZ domain 2), and 670 nM for PSD-95d1[1]. Tat-NR2B9c also reduces NMDA-induced p38 activation, and possesses neuroprotective efficacy[2]. EC50: 6.7 nM (PSD-95d2), 670 nM (PSD-95d1)[1]p38[2]

[1]. Cui H, et al. PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J Neurosci. 2007 Sep 12;27(37):9901-15. [2]. Fan J, et al. P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease. Neurobiol Dis. 2012 Mar;45(3):999-1009.