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Osthenol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Osthenol图片
CAS NO:484-14-0
包装:1mg
市场价:1080元

产品介绍
Osthenol(Ostenol)是从独活干根中分离得到的一种前酰化香豆素,是一种可逆的,选择性的竞争性人单胺氧化酶-A(hMAO-A)抑制剂(Ki=0.26µM)。Osthenol对重组hMAO-A具有潜在的选择性抑制作用,IC50为0.74µM,对hMAO-A和hMAO-B表现出较高的选择性指数。
Cas No.484-14-0
别名7-羟基-8-(3-甲基-2-丁烯)-二氢苯并吡喃,Ostenol
Canonical SMILESO=C1C=CC2=CC=C(O)C(C/C=C(C)\C)=C2O1
分子式C14H14O3
分子量230.26
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM). Osthenol potently inhibits recombinant hMAO-A with an IC50 of 0.74 µM and shows a high selectivity index for hMAO-A versus hMAO-B[1].

[1]. Baek SC, et al. Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity. Bioorg Med Chem Lett. 2019;29(6):839-843. [2]. Liao ZC, et al. Zhongguo Zhong Yao Za Zhi. 2017;42(15):2999-3003.