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Cyclic di-UMP(sodium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cyclic di-UMP(sodium salt)图片
包装:600µg
市场价:3009元

产品介绍
A pyrimidine-containing CDN
Canonical SMILES[O-]P1(OC[C@@]2([H])O[C@](N3C=CC(NC3=O)=O)([H])[C@H](O)[C@@]2(OP([O-])(OC[C@]([H])([C@]4(O1)[H])O[C@](N5C=CC(NC5=O)=O)([H])[C@@H]4O)=O)[H])=O.[Na+].[Na+]
分子式C18H20N4O16P2•2Na
分子量656.3
溶解度Water: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cyclic di-UMP is a pyrimidine-containing cyclic dinucleotide (CDN).1It is produced by bacterial cGAS/DncV-like nucleotidyltransferases (CD-NTases), such as LpCdnE02 fromL. pneumophila, and binds to cGAS, in the apo or dsDNA-bound forms, with reduced affinity compared to 2'3'-cGAMP or 3'3'-cGAMP .1,2Cyclic di-UMP is intended for use as a negative control for cyclic di-GMP signaling.

1.Whiteley, A.T., Eaglesham, J.B., de Oliveira Mann, C.C., et al.Bacterial cGAS-like enzymes synthesize diverse nucleotide signalsNature564(7747)194-199(2019) 2.Hall, J., Ralph, E.C., Shanker, S., et al.The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibitionProtein Sci.26(12)2367-2380(2017)