| 包装: | 600µg |
| 市场价: | 3009元 |
| Canonical SMILES | [O-]P1(OC[C@@]2([H])O[C@](N3C=CC(NC3=O)=O)([H])[C@H](O)[C@@]2(OP([O-])(OC[C@]([H])([C@]4(O1)[H])O[C@](N5C=CC(NC5=O)=O)([H])[C@@H]4O)=O)[H])=O.[Na+].[Na+] |
| 分子式 | C18H20N4O16P2•2Na |
| 分子量 | 656.3 |
| 溶解度 | Water: soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Cyclic di-UMP is a pyrimidine-containing cyclic dinucleotide (CDN).1It is produced by bacterial cGAS/DncV-like nucleotidyltransferases (CD-NTases), such as LpCdnE02 fromL. pneumophila, and binds to cGAS, in the apo or dsDNA-bound forms, with reduced affinity compared to 2'3'-cGAMP or 3'3'-cGAMP .1,2Cyclic di-UMP is intended for use as a negative control for cyclic di-GMP signaling. 1.Whiteley, A.T., Eaglesham, J.B., de Oliveira Mann, C.C., et al.Bacterial cGAS-like enzymes synthesize diverse nucleotide signalsNature564(7747)194-199(2019) 2.Hall, J., Ralph, E.C., Shanker, S., et al.The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibitionProtein Sci.26(12)2367-2380(2017) |
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