Masupirdine free base

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

701205-60-9

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议

产品介绍

Masupirdine free base (SUVN-502 free base) 是一种有效的，选择性的，具有口服生物可利用且可穿透脑屏障的5-HT6 受体拮抗剂 (对人 5-HT6 受体的 Ki 为 2.04 nM)。Masupirdine free base (SUVN-502 free base) 对 5-HT2A 受体和其他 100个靶点显示高选择性，有治疗阿尔茨海默病的潜力。

Cas No.	701205-60-9
别名	SUVN-502 free base
Canonical SMILES	O=S(N1C2=CC=C(OC)C=C2C(CN3CCN(C)CC3)=C1)(C(C=CC=C4)=C4Br)=O
分子式	C₂₁H₂₄BrN₃O₃S
分子量	478.4
溶解度	Soluble in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Masupirdine free base (SUVN-502 free base) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). Masupirdine free base (SUVN-502 free base) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease[1]. Ki: 2.04 nM (human 5-HT6 receptor)[1] [1]. Nirogi R, et al. Discovery and Development of 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT6) Receptor Antagonist for Potential Treatment of Alzheimer's Disease. J Med Chem. 2017 Mar 9;60(5):1843-1859.