CAS NO: | 1364488-67-4 |
规格: | ≥98% |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
1g | 电议 |
Molecular Weight (MW) | 504.41 |
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Formula | C25H27Cl2N3O4 |
CAS No. | 1364488-67-4 |
Storage | -20℃ for 3 years in powder form |
-80℃ for 2 years in solvent | |
Solubility (In vitro) | DMSO: 100 mg/mL (198.3 mM) |
Water:<1 mg/mL (slightly soluble or insoluble) | |
Ethanol: 18 mg/mL (35.7 mM) | |
Other info | Synonym: YH239-EE; YH239EE; YH239 EE; YH239 Ethylester; Chemical Name: Ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate InChi Key: OTUBDDRFPQLPKD-UHFFFAOYSA-N InChi Code: InChI=1S/C25H27Cl2N3O4/c1-5-34-24(33)21-20(18-11-10-17(27)12-19(18)28-21)22(23(32)29-25(2,3)4)30(14-31)13-15-6-8-16(26)9-7-15/h6-12,14,22,28H,5,13H2,1-4H3,(H,29,32) SMILES Code: O=C(C(N1)=C(C(N(CC2=CC=C(Cl)C=C2)C=O)C(NC(C)(C)C)=O)C3=C1C=C(Cl)C=C3)OCC |
Chemical Name | Ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate |
In Vitro | YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion). |
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In Vivo | N/A |
Animal model | N/A |
Formulation & Dosage | N/A |
References | [1] Huang Y, et al. ACS Chem Biol. 2014, 9(3), 802-811. |
Huang Y, et al. ACS Chem Biol. 2014, 9(3), 802-811.
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