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Thiacetazone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Thiacetazone图片
CAS NO:104-06-3
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Thiacetazone (Thioacetazone) 是一种含硫脲的抗结核剂,也是一种具有口服活性抗生素。Thiacetazone 具有抗菌作用,可抑制结核分枝杆菌 H37Rv (Mycobacterium tuberculosis H37Rv) 的生长,其 MIC 值为 0.1 μg/mL。
Cas No.104-06-3
别名氨硫脲; Thioacetazone; Amithiozone
Canonical SMILESCC(NC1=CC=C(/C=N/NC(N)=S)C=C1)=O
分子式C10H12N4OS
分子量236.29
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Thiacetazone (Thioacetazone) is a thiourea-containing antitubercular agent and is an orally active antibiotic. Thiacetazone has antibacterial action, which inhibits growth of Mycobacterium tuberculosis H37Rv with a MIC value of 0.1 μg/mL[1].

[1]. J L Stigliani, et al. New Insights Into the Chemical Behavior of S-oxide Derivatives of Thiocarbonyl-Containing Antitubercular Drugs and the Influence on Their Mechanisms of Action and Toxicity. Ann Pharm Fr. 2019 Mar;77(2):126-135. [2]. P Khanna, et al. Characteristics of a Cytosolic Arylacylamidase Metabolizing Thiacetazone. J Pharmacol Exp Ther. 1992 Sep;262(3):1225-31. [3]. Anuradha Alahari, et al. Thiacetazone, an Antitubercular Drug That Inhibits Cyclopropanation of Cell Wall Mycolic Acids in Mycobacteria. PLoS One. 2007 Dec 19;2(12):e1343. [4]. C A Peloquin, et al. Pharmacokinetic Evaluation of Thiacetazone. Pharmacotherapy. Sep-Oct 1996;16(5):735-41.