| CAS NO: | 166403-66-3 |
| 包装: | 1mg |
| 市场价: | 10800元 |
Tenofovirdiphosphate(TFV-DP)是一种ATP竞争性的DNA聚合酶(DNApolymerases)抑制剂，且是1型HIV(HIV-1)逆转录酶(RT)的底物。
| Cas No. | 166403-66-3 |
| 别名 | 泰诺福韦二乙胺盐(异构体混合物),TFV-DP |
| Canonical SMILES | C[C@@H](OC[P](O[P](O[P](O)(O)=O)(O)=O)(O)=O)CN1C2=NC=NC(N)=C2N=C1 |
| 分子式 | C9H16N5O10P3 |
| 分子量 | 447.17 |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Tenofovir diphosphate (TFV-DP) is a competitive DNA polymerases inhibitor (with respect to dATP) and a substrate of HIV type 1 (HIV-1) reverse transcriptase (RT)[1]. Tenofovir diphosphate acts as an inhibitor of DNA pol. Tenofovir-diphosphate is a weak inhibitor of DNA polymerases (pol) α, δ, and ?, with values for the Ki for PMPApp (PMPAppKi) relative to the Km for dATP (dATPKm) of 10.2, 10.2, and 15.6, respectively[1]. [1]. Gabriel Birkus, et al. Tenofovir Diphosphate Is a Poor Substrate and a Weak Inhibitor of Rat DNA Polymerases Alpha, Delta, and epsilon. Antimicrob Agents Chemother. 2002 May;46(5):1610-3. |
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