CAS NO: | 545380-34-5 |
规格: | ≥98% |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
Molecular Weight (MW) | 356.42 |
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Formula | C22H20N4O |
CAS No. | 545380-34-5 |
Storage | -20℃ for 3 years in powder form |
-80℃ for 2 years in solvent | |
Solubility (In vitro) | DMSO: 5 mg/mL warming (14.0 mM) |
Water:<1 mg/mL (slightly soluble or insoluble) | |
Ethanol: <1 mg/mL (slightly soluble or insoluble) | |
Solubility (In vivo) | 0.5% hydroxyethyl cellulose: 30 mg/mL |
Synonyms/Chemical Name | CAY10470; CAY-10470; CAY 10470; EVP4593; EVP 4593; EVP-4593; 4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine |
In Vitro | EVP4593 inhibits TNF-a production from murine splenocytes stimulated with LPS with IC50 of 7 nM. EVP4593 (300 nM) entails a significant decrease of amplitude of store-operated currents (approximately by 60%), induced by application of 1 μM thapsigargin in Htt138Q cells, thus prevents abnormal store-operated calcium entry. |
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In Vivo | EVP4593 (1 mg/kg, i.p.) dose-dependently inhibits carrageenin-induced paw edema in rats. |
Animal model | male SD rats with carrageenin induced paw edema |
Formulation & Dosage | 0.5% hydroxypropyl cellulose; 1 mg/kg; i.p injection |
References | [1] Tobe M, et al. Bioorg Med Chem, 2003, 11(3), 383-391. |
Identification of EVP4593 in climbing assay screen with HD transgenic flies. Chem Biol. 2011 Jun 24;18(6):777-93 | SOC pathway in WT and YAC128 MSNs - Ca2+ imaging assay. Chem Biol. 2011 Jun 24;18(6):777-93 | Compounds from EVP4593 series or knockdown of TRPC1 protect YAC128 MSNs from glutamate-induced apoptosis. Chem Biol. 2011 Jun 24;18(6):777-93 |