CAS NO: | 518058-84-9 |
包装 | 价格(元) |
10mM (in 1mL DMSO) | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
Cas No. | 518058-84-9 |
化学名 | 5-fluoro-N-(3-hydroxybenzyl)-1H-indole-2-carboxamide |
Canonical SMILES | FC1=CC(C=C(C(NCC2=CC=CC(O)=C2)=O)N3)=C3C=C1 |
分子式 | C16H13FN2O2 |
分子量 | 284.29 |
溶解度 | ≥ 10.1mg/mL in DMSO |
储存条件 | Store at -20℃ |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | KX1-004 is a non-ATP competitive inhibitor of pp60c-src with IC50 value of 40 μM [1]. KX1-004 is a close analog of the indole-based Src-PTK inhibitors reported previously. It has a 5-fluoro group and showed potent inhibition activity in isolated Src-PTK assay. KX1-004 was found to have protective effect in noise-induced hearing loss. The chinchillas treated with 30 μM KX1-004 were exposed to continuous noise. And the results showed that treated ears exhibited up to 40 dB less threshold shift (TTS) and up to 25 dB less permanent threshold shift (PTS) than control ears. KX1-004 treatment also significantly reduced outer hair cell (OHC) loss than control. Besides that, KX1-004 was proved to reduce the hearing loss and hair cell loss associated with impulse noise exposure markedly [1, 2]. References: |