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Demethylasterriquinone B1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Demethylasterriquinone B1图片
CAS NO:78860-34-1
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
Demethylasterriquinone B1 是一种选择性胰岛素受体激活剂。
Cas No.78860-34-1
别名DMAQ B1, L-783,281
化学名2,5-dihydroxy-3-(7-(3-methylbut-2-en-1-yl)-1H-indol-3-yl)-6-(2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl)cyclohexa-2,5-diene-1,4-dione
Canonical SMILESOC(C1=O)=C(C(C(O)=C1C(C2=CC=C3)=CNC2=C3C/C=C(C)\C)=O)C4=C(C(C)(C=C)C)NC5=CC=CC=C45
分子式C32H30N2O4
分子量506.59
溶解度10mg/mL in DMSO, 15mg/mL in DMF, 10mg/mL in Ethanol
储存条件Desiccate at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
文献引用
产品描述

Demethylasterriquinone B1 (DMAQ B1) is a natural insulin mimic that activates insulin receptor tyrosine kinase (IRTK; EC50 = 6 μM).[1],[2],[3],[4] It less potently activates IGF1R and EGFR (EC50s = 100 μM for both). DMAQ B1 induces glucose uptake in adipocytes and skeletal muscle cells without activating proliferation. DMAQ B1 binds GAPDH in vitro.[5]

Reference:
[1]. Salituro, G.M., Pelaez, F., and Zhang, B.B. Discovery of a small molecule insulin receptor activator. Recent Prog. Horm. Res. 56, 107-126 (2001).
[2]. Tsai, H.J., and Chou, S.Y. A novel hydroxyfuroic acid compound as an insulin receptor activator. Structure and activity relationship of a prenylindole moiety to insulin receptor activation. J. Biomed. Sci. 16(68), (2009).
[3]. Weber, M.A., Lidor, A., Arora, S., et al. A novel insulin mimetic without a proliferative effect on vascular smooth muscle cells. J. Vasc. Surg. 32(6), 1118-1126 (2000).
[4]. Webster, N.J.G., Park, K., and Pirrung, M.C. Signaling effects of demethylasterriquinone B1, a selective insulin receptor modulator. Chembiochem. 4(5), 379-385 (2003).
[5]. Kim, H., Deng, L., Xiong, X., et al. Glyceraldehyde 3-phosphate dehydrogenase is a cellular target of the insulin mimic demethylasterriquinone B1. J. Med. Chem. 50(15), 3423-3426 (2007).