HKI 357 是一种不可逆的 EGFR 和 ERBB2 双重抑制剂，IC50 分别为 34 nM 和 33 nM。 HKI 357 抑制 EGFR 自磷酸化（在 Y1068）以及 AKT 和 MAPK 磷酸化。
| Cas No. | 848133-17-5 |
| 化学名 | (E)-N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide |
| Canonical SMILES | ClC1=CC(NC(C2=C3)=C(C#N)C=NC2=CC(OCC)=C3NC(/C=C/CN(C)C)=O)=CC=C1OCC4=CC=CC(F)=C4 |
| 分子式 | C31H29ClFN5O3 |
| 分子量 | 574.05 |
| 溶解度 | DMSO: 100 mM,Ethanol: 25 mM |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
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