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PF 06465469
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF 06465469图片
CAS NO:1407966-77-1
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
PF 06465469 是 ITK 的共价抑制剂,IC50 为 2 nM。
Cas No.1407966-77-1
化学名(R)-3-(1-(1-acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-isopropyl-3-methylphenyl)benzamide
Canonical SMILESC=CC(N1CCC[C@](N2C3=NC=NC(N)=C3C(C4=CC(C(NC(C=C5C)=CC=C5C(C)C)=O)=CC=C4)=N2)([H])C1)=O
分子式C30H33N7O2
分子量523.63
溶解度<2.62mg/ml in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PF-06465469 is a covalent inhibitor of ITK with an IC50 of 2 nM[1].

References:
[1]. Mamand S, et al. Comparison of interleukin-2-inducible kinase (ITK) inhibitors and potential for combination therapies for T-cell lymphoma. Sci Rep. 2018 Sep 21;8(1):14216.